Naturally Occurring Human Antibodies
نویسندگان
چکیده
Human serum antibodies which react different pepsin-digested IgA proteins only with antigenic determinants rewas found in individual sera but no revealed by digestion of IgA with pepsin lationship to either IgA subgroups or were found in 29.2 per cent of the sera genetically determined IgA antigens was from 369 hospitalized patients studied. discerned. The presence of these antiThese antibodies were shown to be speIgA antibodies was not found to be recific for sites on the F(ab’)9a fragment of lated to specific disease processes or to IgA and were dependent upon intact alterations in serum immunoglobulin disulfide bonds for antigenicity. Conconcentrations. siderable variability in reactivity with
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